The region has the second worst figures for deaths in England and Wales.
New data from the Office for National Statistics has shown only the West Midlands has a higher rate.
Across the area nearly five deaths occur per one-thousand within the first 12 months of being born.
That compares with six deaths per one-thousand in the worst region, and just over three per one-thousand in the best (East England). The infant mortality rate for Wales was three deaths per one-thousand.
The figures released were based on those to year-end 2016, when 2,651 infant (those under 1 years-old) deaths were recorded, slightly up on the 2015 figures of 2,578. The mortality rate has generally been following a downward trend since the 1990s.
For England and Wales, rates are significantly better than those from the mid-1980s - in 1986 the rate was 6,313, nearly two-and-a-half times the latest rates published.
For the whole of England infant mortality rates are still higher in socially and economically deprived areas, compared with the least deprived areas, with the rate being more than half that of more affluent regions.
Ethnic minorities are still suffering with the worst mortality rates nationally, although figures are improving.
The report went on to name cancer as still the most common killer of children aged between 1 to 15 years.
Cheshire’s Museum of Policing receives King’s Award for Voluntary Service
Constabulary intensifying efforts regarding the sale of knives during week-long operation
Man handed CBO following shoplifting and vehicle interference
Appeal for witnesses following fatal collision in Sandbach
Operation Crossbow targets wanted criminals across the county
Swim sessions available for users with vision impairments at Brio Northwich
Macclesfield Youth Brass Band Receives The King’s Award for Voluntary Service
Connecting Chelford receives The King’s Award for Voluntary Service
Ofsted recognise ‘a level of optimism and confidence’ in Cheshire East children’s services
New housing charter for care leavers launched as council celebrates Care Leavers’ Month
King’s Shoots and Scores on International and National Courts
Shadow artworks to be created to raise awareness of men’s mental health
Prolific burglar jailed for Northwich crime spree
Two men charged with Macclesfield burglary
Congleton Unites in Record Numbers for Remembrance
Public urged to help find wanted man Lee Scanlon
Image released following distraction theft in Crewe
Northwich man jailed for assaulting ex-partner
Congleton Town Council is speaking up for women and girls
Man jailed following Northwich ram raid
